Dr. Rossignol’s Articles and Publications
77 Publications
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Published 2024 ( 2 Articles )
Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis
R. E. Frye, N. Rincon, P. J. McCarty, D. Brister, A. C. Scheck and D. A. Rossignol
Neurobiol Dis 2024 Vol. 197 Pages 106520Binding Folate Receptor Alpha Autoantibody Is a Biomarker for Leucovorin Treatment Response in Autism Spectrum Disorder
Frye RE, McCarty PJ, Werner BA, Scheck AC, Collins HL, Adelman SJ, Rossignol DA, Quadros EV, J Pers Med 2024;14(1):62
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Published 2023 ( 3 Articles )
Neurobiology of Autism Spectrum Disorder
Casanova, M. F., J. N. Constantino, C. Ecker, R. E. Frye, V. Martinez-Cerdeño, D. A. Rossignol and S. W. Scherer (2020). Neurobiology of Autism Spectrum Disorder. Tasman’s Psychiatry. A. Tasman, M. B. Riba, R. D. Alarcón et al. Cham, Springer International Publishing: 1-38.
Age-Related Changes in Epilepsy Characteristics and Response to Antiepileptic Treatment in Autism Spectrum Disorders
Gundogdu BS, Gaitanis J, Adams JB, Rossignol DA, Frye RE. Age-Related Changes in Epilepsy Characteristics and Response to Antiepileptic Treatment in Autism Spectrum Disorders. J Pers Med 2023;13(7):1167
The Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medical Care of Autism Spectrum Disorder
Indika N.L.R., Frye R.E., Rossignol D.A., Owens S.C., Senaratne U.D., Grabrucker A.M., Perera R., Engelen M.P.K.J., Deutz N.E.P. J Pers Med 2023; 13(2), 252
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Published 2022 (5 Articles)
Psychotropic Medications for Sleep Disorders in Autism Spectrum Disorders
Rossignol DA, Frye RE. Psychotropic Medications for Sleep Disorders in Autism Spectrum Disorders. In Handbook of Autism and Pervasive Developmental Disorder, 2022. Edited by Johnny L. Matson and Peter Sturmey, Springer Publishing.
The Soluble Folate Receptor in Autism Spectrum Disorder: Relation to Autism Severity and Leucovorin Treatment
Frye R.E, Lane A., Worner A., Werner B.A., McCarty P.J., Scheck A.C., Collins H.L., Adelman S.J., Quadros E.V., Rossignol D.A. J Pers Med 2022; 12(12):2033
Long COVID Syndrome Presenting as Neuropsychiatric Exacerbations in Autism Spectrum Disorder: Insights for Treatment
Jyonouchi H., Geng L., Rossignol D.A. and Frye R.E. J Pers Med 2022; 12(11):1815
A Personalized Approach to Evaluating and Treating Autism Spectrum Disorder
R. E. Frye, S. Rose, R. G. Boles, D. A. Rossignol. J Pers Med 2022; 12(2):147
Evidence for Mitochondrial Dysfunction in Psychiatric Disease
R. E. Frye and D. A. Rossignol. In: Mitochondria and Neurological Disorders, edited by D. R. Sandhir, 2022
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Published 2021 (4 Articles)
Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in Autism Spectrum Disorders: A Systematic Review and Meta-Analysis.
D. A. Rossignol and R. E. Frye. J Pers Med 2021;11(11):1141.
Ratings of the Effectiveness of Nutraceuticals for Autism Spectrum Disorders: Results of a National Survey
J. B. Adams, A. Bhargava, D. M. Coleman, R. E. Frye and D. A. Rossignol. J Pers Med 2021 Vol. 11 Issue 9 Page 878
A Systematic Review and Meta-Analysis of Immunoglobulin G Abnormalities and the Therapeutic Use of Intravenous Immunoglobulins (IVIG) in Autism Spectrum Disorder
D. A. Rossignol and R. E. Frye. J Pers Med 2021 Vol. 11 Issue 6 Pages 488
The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
D. A. Rossignol and R. E. Frye. J Pers Med 2021 Vol. 11 Issue 8 Pages 784
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Published 2020 (1 Article)
Treatment of Folate Metabolism Abnormalities in Autism Spectrum Disorder
Frye RE, Rossignol DA, Scahill L, McDougle CJ, Huberman H, Quadros EV. Treatment of Folate Metabolism Abnormalities in Autism Spectrum Disorder. Semin Pediatr Neurol 2020; 100835
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Published 2019 (1 Article)
Emerging biomarkers in autism spectrum disorder: a systematic review
Frye RE, Vassall S, Kaur G, Lewis C, Karim M, Rossignol DA. Emerging biomarkers in autism spectrum disorder: a systematic review. Ann Transl Med 2019;7(23):792
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Published 2018 (2 Articles)
The use of NAC as a chelator for metal toxicity: a systematic review [Book chapter].
In The Therapeutic Use of N-Acetyl Cysteine in Medicine, 2018. Rossignol DA. Edited by Richard Frye and Michael Berk, Springer Publishing.
Clinical and molecular characteristics of mitochondrial dysfunction in autism spectrum disorder
Mol Diagn Ther 2018; doi: 10.1007/s40291-018-0352-x. Rose S, Niyazov DM, Rossignol DA, Goldenthal M, Kahler SG, Frye RE.
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Published 2016 (2 Articles)
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Published 2015 (3 Articles)
Mitochondrial physiology in psychiatric disorders
Edited by Donald Armstrong, Anna Dietrich-Maszalska, Sylvain Gagnon and Ved Chauhan, Springer Science, 2014
Hyperbaric oxygen treatment in autism spectrum disorders
Edited by Donald Armstrong, Anna Dietrich-Maszalska, Sylvain Gagnon and Ved Chauhan, Springer Science, 2014
S.17.02 The role of melatonin in the treatment of ASD
European Neuropsychopharmacology 25:S137
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Published 2014 (8 Articles)
The use of medications approved for Alzheimer’s disease in autism spectrum disorder: a systematic review
Front Pediatr 2014;2:87
Treatments for biomedical abnormalities associated with autism spectrum disorder
Front Pediatr 2014;2:66
Folate receptor alpha autoantibodies modulate thyroid function in autism spectrum disorder
N A J Med Sci. 2014;7(2):53-56
Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism
Front Physiol 2014;5:150
Environmental toxicants and autism spectrum disorders: a systematic review
Transl Psychiatry 2014;4:e360
Achieving optimal outcomes in autism: Treating potentially reversible conditions associated with autism spectrum disorder
Edited by Valarie Hu, World Scientific, 2014
Cerebral folate deficiency in autism spectrum disorders
Edited by Ken Siri and Toby Lyons, Skyhorse Publishing, 2014
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Published 2013 (6 Articles)
Dr. Rossignol’s editorial in the Orange County Register: More funding needed to study autism
October 18, 2013
A review of traditional and novel treatments for seizures in autism spectrum disorder: Findings from a systematic review and expert panel
Front Public Health 2013;1:31
Cerebral folate receptor autoantibodies in autism spectrum disorder
Mol Psychiatry 2013;18(3):369-81
Interrelationships among the gut, mitochondrial function, and neurological sequelae
Edited by Teri Arranga, Claire I. Viadro and Lauren Underwood, Skyhorse Publishing, 2013
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Published 2012 (13 Articles)
Mitochondrial dysfunction in autism spectrum disorders; a systematic review and meta-analysis
Mol Psychiatry 2012;17(3):290-314
Cerebral folate deficiency in autism spectrum disorders
Edited by Ken Siri and Toby Lyons, Skyhorse Publishing, 2012
Folate receptor alpha autoimmunity and cerebral folate deficiency in autism spectrum disorders
J Ped Biochem 2012;2(4):263-271
Treatments for mitochondrial dysfunction associated with autism spectrum disorders
J Ped Biochem 2012;2(4);241-249
Metabolic disorders and abnormalities associated with autism spectrum disorder
J Ped Biochem 2012;2(4);181-191
Mitochondrial and metabolic abnormalities in neurodevelopmental disorders
J Ped Biochem 2012;2(4);177-180
A consensus statement from the Elias Tembenis seizure think tanks
Autism Sci Digest 2012;5:4-10
Interrelationships among the gut, mitochondrial function, and neurological sequelae
Autism Sci Dig 2012;4:57-65
Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis
Med Gas Res 2012;2(1):6
A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures
Mol Psychiatry 2012;17(4):389-401
Substantial problems with measuring brain mitochondrial dysfunction in autism spectrum disorder using magnetic resonance spectroscopy
J Autism Dev Disord 2012;42(4):640-2
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Published 2011 (5 Articles)
Mitochondrial dysfunction and autism spectrum disorders: a simplified approach
Autism Sci Dig 2011;2:20-27
Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders
Pediatr Res 2011;69(5 Pt 2):41R-7R
Frye and Rossignol reply: Response to meta-analyzing the effectiveness of melatonin for sleep-distrubed individuals with autism spectrum conditions: Should Rett syndrome be included?
Dev Med Child Neurol 2011;53(11):1064
Melatonin in autism spectrum disorders: a systematic review and meta-analysis
Dev Med Child Neurol 2011;53(9):783-92
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Published 2010 (1 Article)
Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder
Altern Med Rev 2010;15(1):15-32
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Published 2009 (8 Articles)
Review of the pathophysiology of autism and possible benefits of hyperbaric oxygen therapy (HBOT)
Integrated Healthcare Practitioners Magazine 2009; Dec/Jan
Industrial chemicals and autism
Integrated Healthcare Practitioners Magazine 2009; Dec/Jan
Novel and emerging treatments for autism spectrum disorders: a systematic review
Ann Clin Psychiatry 2009;21(4):213-236
Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial
BMC Pediatr 2009;9:21
Autism spectrum disorders: Navigating in uncharted waters
Ann Clin Psychiatry 2009;21(3):129-130
Autism spectrum disorders: Rising prevalence drives research on causes and cures
Ann Clin Psychiatry 2009;21(4):193
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Published 2008 (4 Articles)
Our family’s experience with biomedical treatments and hyperbaric oxygen therapy for autism
Autism Sci Dig, 2008
Evidence of mitochondrial dysfunction in autism and implications for treatment
Am J Biochem Biotech 2008;4(2):208-217
The use of hyperbaric oxygen therapy in autism
Edited by J. H. Zhang, Best Publishing Company, 2008
A oxigenoterapia hiperbarica na melhora dos sintomas de autism em criancas [Hyperbaric oxygen therapy in children with autism]
Edited by Efrain Olszewer, 2008
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Published 2007 (4 Articles)
The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study
BMC Pediatr 2007;7(1):36
Hyperbaric oxygen therapy might improve certain pathophysiological findings in autism
Med Hypotheses 2007;68(6):1208-1227
Spironolactone might be a desirable immunologic and hormonal intervention in autism spectrum disorders
Med Hypotheses 2007;68(5):979-987
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Published 2006 (5 Articles)
Hyperbaric oxygen therapy in autistic children improves symptomatology, decreases markers of inflammation, and has neutral effects on oxidative stress [Abstract 25]
NeuroToxicology 2006;27(6);1173
Hyperbaric oxygen therapy may improve symptoms in autistic children
Med Hypotheses 2006;67(2):216-228
Interview with Dr. Dan A. Rossignol: Hyperbaric oxygen therapy may improve symptoms in autistic children in Medical Hypotheses
Medical Veritas 2006;3:944-951
Interview with Dr. Dan A. Rossignol: Hyperbaric oxygen therapy improves symptoms in autistic children
Medical Veritas 2006;3:1-4
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Published 1999 (1 Article)
Accelerated transplant coronary artery disease and massive silent acute myocardial infarction in a heart transplant patient–a case report and brief review of literature
Angiology 1999;50(11):947-953
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Daniel A. Rossignol
NAME AND LICENSE:
Daniel A. Rossignol, Physician
HIGHEST LEVEL OF ACADEMIC DEGREE:
MD
BOARD CERTIFICATION:
American Board of Family
Medicine (ABFM)
Desiree Mills
NAME AND LICENSE:
Desiree Mills, Nurse Practitioner
HIGHEST LEVEL OF ACADEMIC DEGREE:
Master of Science in Nursing
BOARD CERTIFICATION:
American Association of Nurse Practitioners (AANP)
Richard E. Frye
NAME AND LICENSE:
Richard E. Frye, Physician
HIGHEST LEVEL OF ACADEMIC DEGREE:
MD, PhD
BOARD CERTIFICATION:
American Board of Pediatrics (ABP), American Board of Psychiatry and Neurology
Sanaz Demehry
NAME AND LICENSE:
Sanaz Demehry, Physician Assistant
HIGHEST LEVEL OF ACADEMIC DEGREE:
Master’s Degree in Physician Assistant Studies
BOARD CERTIFICATION:
National Commission on Certification of Physician Assistants (NCCPA)
Brian Hauser
NAME AND LICENSE:
Brian Hauser, Physician
HIGHEST LEVEL OF ACADEMIC DEGREE:
MD, MAPS
BOARD CERTIFICATION:
American Board of Family Medicine (ABFM)
Nicole Rincon
NAME AND LICENSE:
Nicole Rincon, Physician Assistant
HIGHEST LEVEL OF ACADEMIC DEGREE:
Master’s Degree in Physician Assistant Studies
BOARD CERTIFICATION:
National Commission on Certification of Physician Assistants (NCCPA)
Cindy Schneider
NAME AND LICENSE:
Cindy Schneider, Physician
HIGHEST LEVEL OF ACADEMIC DEGREE:
MD
BOARD CERTIFICATION:
Medical Academy of Pediatric Special Needs (MAPS), American Board of Obstetricians and Gynecologists
Lanier W. Rossignol
NAME AND LICENSE:
Lanier W. Rossignol, Nurse Practitioner
HIGHEST LEVEL OF ACADEMIC DEGREE:
BSN, MSN, FNP-C
BOARD CERTIFICATION:
American Academy of Nurse Practitioners (AANP) Certification Program
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