64 Publications

  • Published 2020 (1 Article)

    Treatment of Folate Metabolism Abnormalities in Autism Spectrum Disorder

    Frye RE, Rossignol DA, Scahill L, McDougle CJ, Huberman H, Quadros EV. Treatment of Folate Metabolism Abnormalities in Autism Spectrum Disorder. Semin Pediatr Neurol 2020; 100835

  • Published 2019 (1 Article)

    Emerging biomarkers in autism spectrum disorder: a systematic review

    Frye RE, Vassall S, Kaur G, Lewis C, Karim M, Rossignol DA. Emerging biomarkers in autism spectrum disorder: a systematic review. Ann Transl Med 2019;7(23):792

  • Published 2018 (2 Articles)

    The use of NAC as a chelator for metal toxicity: a systematic review [Book chapter].

    In The Therapeutic Use of N-Acetyl Cysteine in Medicine, 2018. Rossignol DA. Edited by Richard Frye and Michael Berk, Springer Publishing.

    Clinical and molecular characteristics of mitochondrial dysfunction in autism spectrum disorder

    Mol Diagn Ther 2018; doi: 10.1007/s40291-018-0352-x.   Rose S, Niyazov DM, Rossignol DA, Goldenthal M, Kahler SG, Frye RE.

  • Published 2016 (2 Articles)

    Environmental toxicants and autism spectrum disorder

    Psychiatric Times 2016;33(9):31-34

    Identification and treatment of pathophysiological comorbidities of autism spectrum disorder to achieve optimal outcomes

    Clin Med Insights Pediatr 2016;10:43-56

  • Published 2015 (3 Articles)

    Mitochondrial physiology in psychiatric disorders

    Edited by Donald Armstrong, Anna Dietrich-Maszalska, Sylvain Gagnon and Ved Chauhan, Springer Science, 2014

    Hyperbaric oxygen treatment in autism spectrum disorders

    Edited by Donald Armstrong, Anna Dietrich-Maszalska, Sylvain Gagnon and Ved Chauhan, Springer Science, 2014

    S.17.02 The role of melatonin in the treatment of ASD

    European Neuropsychopharmacology 25:S137

  • Published 2014 (8 Articles)

    The use of medications approved for Alzheimer’s disease in autism spectrum disorder: a systematic review

    Front Pediatr 2014;2:87

    Treatments for biomedical abnormalities associated with autism spectrum disorder

    Front Pediatr 2014;2:66

    Folate receptor alpha autoantibodies modulate thyroid function in autism spectrum disorder

    N A J Med Sci. 2014;7(2):53-56

    Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism

    Front Physiol 2014;5:150

    Environmental toxicants and autism spectrum disorders: a systematic review

    Transl Psychiatry 2014;4:e360

    Achieving optimal outcomes in autism: Treating potentially reversible conditions associated with autism spectrum disorder

    Edited by Valarie Hu, World Scientific, 2014

    Cerebral folate deficiency in autism spectrum disorders

    Edited by Ken Siri and Toby Lyons, Skyhorse Publishing, 2014

    Melatonin in autism spectrum disorder

    Curr Clin Pharmacol 2013

  • Published 2013 (6 Articles)

    My experience learning about autism

    GAHMJ 2013;2(6):74-77

    Dr. Rossignol’s editorial in the Orange County Register: More funding needed to study autism

    October 18, 2013

    A review of traditional and novel treatments for seizures in autism spectrum disorder: Findings from a systematic review and expert panel

    Front Public Health 2013;1:31

    Mitochondrial physiology in autism spectrum disorders

    OA Autism 2013;1(1):5

    Cerebral folate receptor autoantibodies in autism spectrum disorder

    Mol Psychiatry 2013;18(3):369-81

    Interrelationships among the gut, mitochondrial function, and neurological sequelae

    Edited by Teri Arranga, Claire I. Viadro and Lauren Underwood, Skyhorse Publishing, 2013

  • Published 2012 (13 Articles)

    Mitochondrial dysfunction in autism spectrum disorders; a systematic review and meta-analysis

    Mol Psychiatry 2012;17(3):290-314

    Cerebral folate deficiency in autism spectrum disorders

    Edited by Ken Siri and Toby Lyons, Skyhorse Publishing, 2012

    Folate receptor alpha autoimmunity and cerebral folate deficiency in autism spectrum disorders

    J Ped Biochem 2012;2(4):263-271

    Treatments for mitochondrial dysfunction associated with autism spectrum disorders

    J Ped Biochem 2012;2(4);241-249

    Metabolic disorders and abnormalities associated with autism spectrum disorder

    J Ped Biochem 2012;2(4);181-191

    Mitochondrial and metabolic abnormalities in neurodevelopmental disorders

    J Ped Biochem 2012;2(4);177-180

    A consensus statement from the Elias Tembenis seizure think tanks

    Autism Sci Digest 2012;5:4-10

    Hyperbaric oxygen treatment in autism spectrum disorders

    Med Gas Res 2012;2(1):16

    Interrelationships among the gut, mitochondrial function, and neurological sequelae

    Autism Sci Dig 2012;4:57-65

    Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis

    Med Gas Res 2012;2(1):6

    A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures

    Mol Psychiatry 2012;17(4):389-401

    The folate factor

    Autism File 2012;43:42-46

    Substantial problems with measuring brain mitochondrial dysfunction in autism spectrum disorder using magnetic resonance spectroscopy

    J Autism Dev Disord 2012;42(4):640-2

  • Published 2011 (5 Articles)

    Cerebral folate deficiency in autism spectrum disorders

    Autism Sci Dig 2011;2:9-15

    Mitochondrial dysfunction and autism spectrum disorders: a simplified approach

    Autism Sci Dig 2011;2:20-27

    Mitochondrial dysfunction can connect the diverse medical symptoms associated with autism spectrum disorders

    Pediatr Res 2011;69(5 Pt 2):41R-7R

    Frye and Rossignol reply: Response to meta-analyzing the effectiveness of melatonin for sleep-distrubed individuals with autism spectrum conditions: Should Rett syndrome be included?

    Dev Med Child Neurol 2011;53(11):1064

    Melatonin in autism spectrum disorders: a systematic review and meta-analysis

    Dev Med Child Neurol 2011;53(9):783-92

  • Published 2010 (1 Article)

    Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder

    Altern Med Rev 2010;15(1):15-32

  • Published 2009 (8 Articles)

    Review of the pathophysiology of autism and possible benefits of hyperbaric oxygen therapy (HBOT)

    Integrated Healthcare Practitioners Magazine 2009; Dec/Jan

    Industrial chemicals and autism

    Integrated Healthcare Practitioners Magazine 2009; Dec/Jan

    Novel and emerging treatments for autism spectrum disorders: a systematic review

    Ann Clin Psychiatry 2009;21(4):213-236

    Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial

    BMC Pediatr 2009;9:21

    Diagnosis autism: Now what? A simplified biomedical approach

    Autism File 2009;32:8-11

    The use of hyperbaric oxygen in autism

    Edited by William Shaw, 2009

    Autism spectrum disorders: Navigating in uncharted waters

    Ann Clin Psychiatry 2009;21(3):129-130

    Autism spectrum disorders: Rising prevalence drives research on causes and cures

    Ann Clin Psychiatry 2009;21(4):193

  • Published 2008 (4 Articles)

    Our family’s experience with biomedical treatments and hyperbaric oxygen therapy for autism

    Autism Sci Dig, 2008

    Evidence of mitochondrial dysfunction in autism and implications for treatment

    Am J Biochem Biotech 2008;4(2):208-217

    The use of hyperbaric oxygen therapy in autism

    Edited by J. H. Zhang, Best Publishing Company, 2008

    A oxigenoterapia hiperbarica na melhora dos sintomas de autism em criancas [Hyperbaric oxygen therapy in children with autism]

    Edited by Efrain Olszewer, 2008

  • Published 2007 (4 Articles)

    The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study

    BMC Pediatr 2007;7(1):36

    Hyperbaric oxygen therapy might improve certain pathophysiological findings in autism

    Med Hypotheses 2007;68(6):1208-1227

    Spironolactone might be a desirable immunologic and hormonal intervention in autism spectrum disorders

    Med Hypotheses 2007;68(5):979-987

    The use of urinary porphyrins analysis in autism

    Medical Veritas 2007;4(1):1276-1281

  • Published 2006 (5 Articles)

    Hyperbaric oxygen therapy in autistic children improves symptomatology, decreases markers of inflammation, and has neutral effects on oxidative stress [Abstract 25]

    NeuroToxicology 2006;27(6);1173

    Evidence of imparied mercury efflux in autism [Abstract 75]

    Neurotoxicology 27(6):1173

    Hyperbaric oxygen therapy may improve symptoms in autistic children

    Med Hypotheses 2006;67(2):216-228

    Interview with Dr. Dan A. Rossignol: Hyperbaric oxygen therapy may improve symptoms in autistic children in Medical Hypotheses

    Medical Veritas 2006;3:944-951

    Interview with Dr. Dan A. Rossignol: Hyperbaric oxygen therapy improves symptoms in autistic children

    Medical Veritas 2006;3:1-4

  • Published 1999 (1 Article)

    Accelerated transplant coronary artery disease and massive silent acute myocardial infarction in a heart transplant patient–a case report and brief review of literature

    Angiology 1999;50(11):947-953

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